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prognosis 2

HCC 1

MMP7 1

OPN 1

PSG9 1

biomarker 1

biomarkers 1

genetic polymorphism 1

hepatocellular carcinoma 1

metastasis 1

osteopontin (OPN) 1

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract: we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin(OPN).In our previous gene expression profiling study, OPN was identified as one of the leading genes associatedWe focused on OPN to evaluate its prognostic values and important roles in HCC metastasis.A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of

Keywords： osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic

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Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 250-258 doi: 10.1007/s11684-018-0632-1

Abstract: The aim of this study was to investigate the prognostic performance of osteopontin (OPN), matrix metalloproteinasePlasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay.High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reducedPlasma OPN+MMP7+PSG9 elevation in combination was a prognostic factor for OS ( <0.001).OPN was demonstrated to be a risk factor-associated OS in stage I patients with HCC and patients with

Keywords： biomarkers OPN MMP7 PSG9 HCC prognosis